楡根皮 수추출물의 Helicobacter pylori에 대한 항균효과

• Published in: 동의생리병리학회지 Vol. 22; no. 1; pp. 108 - 114
• Main Authors: 윤종현(Jong Hyun Yun), 이종화(Jong Hwa Lee), 김태헌(Tae Heon Kim), 류영수(Yeoung Su Lyu), 강형원(Hyung Won Kang)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 01.02.2008
• Subjects: 한의학
• ISSN: 1738-7698; 2288-2529

Present study was carried out for development of a new herb product with gastroprotective effect. Natural herbs mentioned that have gastrointenstial protective property in Donggeuibogam and reports were evaluated anti-bacterial activity against Helicobacter pylori, then Ulmus davidiana var. japonica Nakai (YGP) were selected. The material used for the test were water extract of Ulmus davidiana var. japonica Nakai. They were tested individually on HCl ethanol-induced gastric lesion in rats showed the most significant effectiveness, respectively. Then YGP was made, and tested on HCl ethanol, indomethacin-induced gastric lesion, shay ulcer and gastric secretion. Conclusions : YGP showed significant effect on HCl ethanol, indomethacin-induced gastric lesion, and Shay ulcer. It can be regarded that the antigastritic and anti-ulcerative effects of YGP is originated from reduction of total acid output identified by gastric secretion test. KCI Citation Count: 6