연자육의 항우울 효과에 대한 뇌부위별 신경전달물질의 변화

• Published in: Seuteureseu yeon-gu (Online) Vol. 16; no. 4; pp. 393 - 400
• Main Authors: 김지현(Ji Hyun Kim), 이규섭(Kyu-Sop Lee), 정혜영(Hye-Young Joung ), 심현수(Hyun Soo Shim), 배현수(Hyunsu Bae), 김경수(Kyung Soo Kim), 심인섭(Insop Shim)
• Format: Journal Article
• Language: Korean
• Published: 대한스트레스학회 01.12.2008
• Subjects: 가정의학; Brain; 세로토닌; 항우울 효과; Neurotransmitter; 도파민; Nelumbinis semen; Antidepressant effect; HPLC; 연자육
• ISSN: 1225-665X; 2234-1668

In the previous study, we examined that a variety of extracts of Nelumbinis semen (NS) have an antidepressant effect on the forced swimming test (FST) in the rat, which is widely used as a behavioral screening test for antidepressant activity of new compounds. Depression-like symptom in n-BuOH extract showed the strongest inhibitory effect on the immobility time and further fractionated n-BuOH with H2O and MeOH (3:7) fraction (NS37) was the most effective on the immobility time on FST. The purpose of the present study was to observe the neurochemical changes on the anti-depressant actions of unknown compounds in the NS37 extract by using HPLC coupled with electrochemical detection (ECD). The results showed that the NS37-10 (10 mg/kg) has a significant increase of dopamine in cortex, hypothalamus, and hippocampus and a significant decrease of dopamine turnover in hypothalamus and hippocampus. These neurochemical actions of NS37 extract could be responsible for the beneficial effect on depression. (Korean J Str Res 2008;16:393∼400) KCI Citation Count: 1