浙貝母 에탄올 추출물의 멜라닌 생성 억제 효과

• Published in: 동의생리병리학회지 Vol. 25; no. 3; pp. 510 - 515
• Main Authors: 하태광(Tae Kwang Ha), 이부균(Boo Kyun Lee), 윤정록(Jeong Rock Yoon), 문연자(Yeun Ja Mun), 우원홍(Won Hong Woo), 박성하(Seong Ha Park), 이장천(Jang Cheon Lee)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 01.06.2011
• Subjects: 한의학; TRP-1; TRP-2; Fritillaria verticillata Willd; tyrosinase; melanin
• ISSN: 1738-7698; 2288-2529

This study was conducted to evaluate the depigmenting properties of ethanol extract from a Fritillaria verticillata Willd. (EFV) in B16F10 cells. Fritillaria verticillata Willd., a perennial herbaceous plant, has been used as a stimulator of mammary gland, expectorant, blood pressure depressant, antitussive agents in Korean herbal medicine. In the present study, we observed that melanin synthesis of B16F10 cells were significantly decreased by EFV without cytotoxicity. However, EFV could not suppress tyrosinase activity in B16F10 cells and mushroom tyrosinase activity. Furthermore, EFV did not effect the protein expression of tyrosinase, tyrosinase-related protein -1 (TRP-1), and TRP-2. These results suggest that EFV inhibited melanin synthesis and the hypopigmentary effect of EVF was not due to regulation of tyrosinase protein. KCI Citation Count: 3