小陷胸湯의 Methicillin 내성 Staphylococcus aureus 에 대한 항균활성 연구

• Published in: 동의생리병리학회지 Vol. 26; no. 6; pp. 886 - 893
• Main Authors: 염대열(Dae Yul Yum), 백동기(Dong Ki Baek), 송용선(Yung Sun Song)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 01.12.2012
• Subjects: 한의학; MRSA infection; Sohamhyung-tang
• ISSN: 1738-7698; 2288-2529

Methicillin-Resistant Staphylococcus aureus (MRSA) is a cephalosporin and beta-lactam antibiotic-resistant strain. In most cases, MRSA is spread from infected patients and infection rates are growing increasingly. Furthermore, increased resistance to antibiotics is causing serious problems in the world. Staphylococcus aureus is responsible for both nosocomial and community-based infections that range from relatively minor skin and soft tissue infections to life-threatening systemic infections. Therefore, there is a need to develop alternative antimicrobial drugs for the treatment of infectious diseases. In this study, we investigated antimicrobial activity of oriental medicine prescription against MRSA. The minimum inhibitory concentration (MIC) of Sohamhyung-tang water extract against S. aureus strains ranged from 500 to 2,000 μg/mL, so we have it confirmed that a strong antibacterial effect. Also, the combinations of Sohamhyung-tang water extract and conventional antibiotics exhibited improved inhibition of MRSA with synergy effect. We suggest that Sohamhyung-tang water extract against MRSA have antibacterial activity, it has potential as alternatives to antibiotic agent. We suggest that the Sohamhyung-tang water extract lead the treatment of bacterial infection to solve the resistance and remaining side-effect problems that are the major weak points of traditional antibiotics. KCI Citation Count: 2