경동맥 손상 및 혈전을 유발한 동물 모델에서 續命湯의 효능 검증

• Published in: 동의생리병리학회지 Vol. 26; no. 5; pp. 732 - 737
• Main Authors: 허은정(Eun Jung Heo), 이인선(In Sun Lee), 강형원(Hyung Won Kang), 전원경(Won Kyung Jeon)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 01.10.2012
• Subjects: 한의학; vascular injury; thrombosis; carotid artery thrombosis model; sokmyong-tang; herbal medicine
• ISSN: 1738-7698; 2288-2529

The aim of this study is examine the protection effect for artery and antithrombotic effect of Sokmyong-tang(SMT; xuming-tang) on carotid artery thrombosis in a rat model. Thirty minutes before FeCl3 treatment, SD rats were intraperitoneal injected with SMT. We tested the effects of SMT on time to occlusion (TTO) in thrombosis model by induced FeCl3 using the laser Doppler flow meter and accessed thrombus weight (TW) inhibition and measured collagen fibers in the vessel after injury using Masson's trichrome stain. SMT(100 mg/kg, i.p.) showed significantly delayed TTO (13.17±1.33 min, P < 0.001) compared to vehicle control group (8.63±0.92 min) and inhibiting effect on TW with 0.72±0.02 mg/mm (P < 0.05). In addition, SMT prevented collagen fibres damage in injured vessel (22.24±4.48%, P < 0.001). These results provide experimental evidence for SMT can be used to prevent vascular injury and thrombosis such as hypertension, arteriosclerosis, and so on. KCI Citation Count: 4