Influence of Prenatal Noise and Music on the Expressions of c-Fos and Nitric Oxide Synthase in the Hippocampus of Rat Pups

• Published in: 동의생리병리학회지 Vol. 21; no. 5; pp. 1291 - 1296
• Main Authors: Su Mi Kim, Sam Jun Lee, Hong Kim, Seung Soo Baek, Yun Hee Sung, Jin Woo Lee, Young Sick Kim, Sung Eun Kim, Mal Soon Shin, Chang Ju Kim, Choong Yeol Lee
• Format: Journal Article
• Language: English
• Published: 한의병리학회 01.10.2007
• Subjects: 한의학
• ISSN: 1738-7698; 2288-2529

The expressions of c-Fos and nitric oxide synthase (NOS) represent neuronal activity and play a crucial role in the shaping of the development of brain. During the late pregnancy, stresses may influence neuronal activity of prenatal rats. In the present study, the effects of prenatal noise and music on the expressions of c-Fos and NOS in the hippocampus of rat pups were investigated. Exposure to the noise during pregnancy decreased c-Fos and NOS expressions in the hippocampus of rat pups, whereas exposure to music during pregnancy increased c-Fos and NOS expressions in the hippocampus of rat pups. The present results show that prenatal music stimulation may increase neuronal activity of rat offspring, whereas exposure to noise during pregnancy may reduce the neuronal activity of offspring. The present study suggests that prenatal stimuli including noise and music could affect the fetal brain development. KCI Citation Count: 0