槐花 물 추출물의 항염증 효과

• Published in: 동의생리병리학회지 Vol. 23; no. 6; pp. 1392 - 1398
• Main Authors: 배기상(Gi Sang Bae), 조범연(Beom Yeon Jo), 김민선(Min Sun Kim), 박경철(Kyoung Chel Park), 구본순(Bon Soon Koo), 서상완(Sang Wan Seo), 김성규(Sung Gyu Kim), 윤승원(Seung-Won Yun), 정원석(Won Seok Jung), 함경완(Kyung Wan Ham), 송호준(Ho Joon Song), 윤명자(Myung Ja Youn), 전호성(Ho Seong Jeon), 권강범(Kang Beom Kwon), 김재효(Jae Hyo Kim), 박성주(Sung Joo Park)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 01.12.2009
• Subjects: 한의학
• ISSN: 1738-7698; 2288-2529

The purpose of this study was to investigate the anti-inflammatory effects of aqueous extract from Sophora Japonica (SJ) on the RAW 264.7 cells. To evaluate the anti-inflammatory effects of SJ, we examined the cytokine productions including nitric oxide (NO), interleukin (IL)-1b, IL-6 and tumor necrosis factor-a (TNF-a) in lipopolysaccharide (LPS)-induced RAW 264.7 cells and also inhibitory mechanisms such as mitogen-activated protein kinases (MAPKs) and nuclear factor kappa b (NF-kB) using Western blot. SJ inhibited LPS-induced production of NO, TNF-a but not of IL-1b and IL-6 in RAW 264.7 cells. SJ inhibited the activation of MAPKs such as extracelluar signal-regulated kinase (ERK 1/2), c-Jun NH2-terminal kinase (JNK) and p38 but not of NF-kB in the LPS-stimulated RAW 264.7 cells. In conclusion, SJ down-regulated LPS-induced NO and TNF-a productions via MAPKs, which could be a clinical basis for inflammatory diseases and autoimmune diseases. The purpose of this study was to investigate the anti-inflammatory effects of aqueous extract from Sophora Japonica (SJ) on the RAW 264.7 cells. To evaluate the anti-inflammatory effects of SJ, we examined the cytokine productions including nitric oxide (NO), interleukin (IL)-1b, IL-6 and tumor necrosis factor-a (TNF-a) in lipopolysaccharide (LPS)-induced RAW 264.7 cells and also inhibitory mechanisms such as mitogen-activated protein kinases (MAPKs) and nuclear factor kappa b (NF-kB) using Western blot. SJ inhibited LPS-induced production of NO, TNF-a but not of IL-1b and IL-6 in RAW 264.7 cells. SJ inhibited the activation of MAPKs such as extracelluar signal-regulated kinase (ERK 1/2), c-Jun NH2-terminal kinase (JNK) and p38 but not of NF-kB in the LPS-stimulated RAW 264.7 cells. In conclusion, SJ down-regulated LPS-induced NO and TNF-a productions via MAPKs, which could be a clinical basis for inflammatory diseases and autoimmune diseases. KCI Citation Count: 2