薔薇根 메탄올 추출물의 혈관이완 기전에 대한 연구

• Published in: 동의생리병리학회지 Vol. 21; no. 2; pp. 408 - 413
• Main Authors: 김대중(Dae Joong Kim), 조남근(Namgeun Cho), 이준경(Jun Kyoung Lee), 조려화(Li Hua Cao), 이혁(Hyuck Lee), 안준석(Jun Seok An), 엄재연(Jae Yeon Um), 조규원(Gue One Joe), 경은호(Eun Ho Kyung), 강대길(Dae Gill Kang), 이호섭(Ho Sub Lee)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 01.04.2007
• Subjects: 한의학
• ISSN: 1738-7698; 2288-2529

Vascular tone plays an important role in the regulation of blood pressure. In the present study, the methanol extract of Rosae multiflora Radix (MRM) induced dose-dependent relaxation of phenylephrine-precontracted aorta, which was abolished by removal of functional endothelium. Pretreatment of the endothelium-intact aortic tissues with NG-nitro-L-arginine methyl ester (L-NAME) or 1H-[1,2,4]-oxadiazole-[4,3-α]-quinoxalin-1-one (ODQ) inhibited the relaxation induced by MRM, respectively. But, the relaxation effect of MRM was not blocked by indomethacine, glibenclamide, tetraethylammonium (TEA), verapamil, diltiazem, atropine, and propranolol, respectively. Moreover, incubation of endothelium-intact aortic rings with MRM increased the production of cGMP. Taken together, the present results suggest that MRM relaxes vascular smooth muscle via endothelium-dependent nitric oxide/cGMP signaling. These results would be useful for further study to MRM on animal models with cardiovascular diseases. KCI Citation Count: 0