連翹散이 아토피 동물 모델에 미치는 영향

• Published in: 동의생리병리학회지 Vol. 20; no. 1; pp. 58 - 64
• Main Authors: 박지수(Jee Su Park), 김윤희(Yun Hee Kim), 강탁림(Tak Lim Kang)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 01.02.2006
• Subjects: 한의학
• ISSN: 1738-7698; 2288-2529

The purpose of this study is to examine closely effect that YKS used to atopic dermatitis disease patient get in atopy eruption control experimentally. We analyzed the expression of IgE, IL-6, IL-4, IL-5 and IL-13's level in serum, and IFN-γ' production by YKS extract. We also analyzed YKS extract get to NC/Nga mice's skin establishment analyzes neck-back skin after biopsy, and H&E method measured about epidermis and dermis part in comparison with control group. In this research YKS extract as treatment result to a NC/Nga mice, IgE and IL-6 content in serum decreased remarkably than control group. And decreased than result control group which measure IL-4, IL-5, IL-13's level in serum, and IFN-γ' production secreted in Th1 cell displayed increase by YKS extract. IL-4 and IFN-γ's gene revelation amount displayed marked decrease than control group in result that observe effect that get in skin of a NC/Nga mice. Also, in culture supernatant which cultivate for 14 day after separate skin cell, IL-13 and IL-6 production decreased than control group. YKS extract get to NC/Nga mice's skin establishment analyzes neck-back skin after biopsy, and dye by H&E method decreased about epidermis and inflammation of dermis part remarkably than control group. These results suggest that Th1 cell and Th2 cell observe to be shifted by secretion amount of IL-4 and IFN-γ by YKS extract could know that YKS extract can use usefully in allergy autoimmune disease. KCI Citation Count: 5