龍膽瀉肝湯合黃連解毒加減의 항염작용에 대한 실험적 연구

• Published in: 동의생리병리학회지 Vol. 21; no. 4; pp. 946 - 954
• Main Authors: 김진경(Jin Kyung Kim), 임현정(Hyun Jung Lim), 신선미(Sun Mi Shin), 김수민(Soo Min Kim), 이정은(Jung Eun Lee), 유동열(Dong Youl Yoo)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 01.08.2007
• Subjects: 한의학
• ISSN: 1738-7698; 2288-2529

The purpose of this research was to investigate the anti-inflammatory effects of Yongdamsagantanghaphwangryunhaedogkagam(YSHHK) which has been medicated the patient such as breast cellulitis. YSHHK did not show any cytotoxic effect on mouse lung fibroblast cells at any of the concentrations evaluated(200, 100, 50, 10, 1 ㎍/㎖). YSHHK in RAW264.7 cell inhibited IL-1β, IL-6, TNF-α, COX-2 and NOS-II mRNA genes expression in a concentration-dependent manner. YSHHK inhibited NO production significantly at the concentration of 100, 50㎍/㎖ and ROS production in a concentration-dependent manner. YSHHK inhibited IL-1β, IL-6 and TNF-α production significantly in serum of mice with LPS-induced acute inflammation. YSHHK increased survival rate of mice with LPS-induced lethal endotoxemia, compared to the control group, from the 3rd day onward. These results suggest that Yongdamsagantanghaphwangryunhaedogkagam(YSHHK) can be useful in treating mammary diseases caused by inflammation such as breast cellulitis. KCI Citation Count: 2