川芎 메탄올 추출액의 멜라닌 형성 억제 효과

• Published in: 동의생리병리학회지 Vol. 19; no. 4; pp. 938 - 944
• Main Authors: 박종훈(Jong Hun Park), 김양진(Yang Jin Kim), 문연자(Yeun Ja Mun), 이영철(Young Cheol Lee), 우원홍(Won Hong Woo)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 01.08.2005
• Subjects: 한의학
• ISSN: 1738-7698; 2288-2529

Down-regulation of melanin synthesis is required for recovery of pigmentary disorders and it is known that direct inhibitors of tyrosinase suppress melanin synthesis. We screened several oriental medicinal plants using B16/F10 cells and found that the methanolic extract of Cnidii Rhizoma down-regulated melanin synthesis effectively. Although the proliferation of B16/F10 cells was decresed by the methanolic extract of Cnidii Rhizoma, it did not appear necrosis. B16/F10 cells incubated with the methanolic extract of Cnidii Rhizoma showed reduced pigmentation and tyrosinase activity. Western blotting revealed that the amount of tyrosinase was decreased by the methanolic extract of Cnidii Rhizoma. These results suggest that the inhibitary effect of the methanolic extract of Cnidii Rhizoma on melanogenesis is due to the suppression of tyrosinase in B16/F10 cells and Cnidii Rhizoma is a candidate for an efficient whitening agent. KCI Citation Count: 6