加味復元通氣散의 항염작용에 대한 실험적 연구

The purpose of this research was to investigate the anti-inflammatory effects of Kamibokwontonggi-san(KBTS) which has been medicated the patient such as mastitis, mammary tuberculosis. KBTS in RAW264.7 cell inhibited IL-1β, IL-6, TNF-α, COX-2 and NOS-II mRNA genes expression in a concentration-depen...

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Published in동의생리병리학회지 Vol. 21; no. 4; pp. 860 - 868
Main Authors 김지혜(Ji Hye Kim), 임현정(Hyun Jung Lim), 신선미(Sun Mi Shin), 김수민(Soo Min Kim), 이정은(Jung Eun Lee), 유동열(Dong Youl Yoo)
Format Journal Article
LanguageKorean
Published 한의병리학회 01.08.2007
Subjects
한의학
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ISSN1738-7698
2288-2529

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Summary:The purpose of this research was to investigate the anti-inflammatory effects of Kamibokwontonggi-san(KBTS) which has been medicated the patient such as mastitis, mammary tuberculosis. KBTS in RAW264.7 cell inhibited IL-1β, IL-6, TNF-α, COX-2 and NOS-II mRNA genes expression in a concentration-dependent manner. KBTS inhibited NO production significantly at 100, 50 ㎍/㎖ and ROS production in a concentration-dependent manner. KBTS inhibited IL-1β, IL-6 and TNF-α production significantly in serum of acute anti-inflammation-induced mice and the survival rate at the 3rd day on LPS-induced lethal endotoxemia. These results suggest that Kamibokwonntonggi-san (KBTS) can be useful in treating a lot of women diseases caused by inflammation such as mastitis, mammary tuberculosis, pelvic inflammatory disease and pelvic tuberculosis. KCI Citation Count: 2
Bibliography:G704-000534.2007.21.4.030
ISSN:1738-7698
2288-2529