澤君六味地黃湯이 산화질소의존형 고혈압백서의 혈압과 신장기능에 미치는 영향

• Published in: 동의생리병리학회지 Vol. 18; no. 1; pp. 84 - 92
• Main Authors: 손은진(Eun Jin Sohn), 강대길(Dae Gill Kang), 노숙연(Suk Yeon Noh), 이안숙(An Sook Lee), 尹明浩(Ming Hao Yin), 문미경(Mi Kyung Moon), 윤용갑(Young Gab Yun), 이호섭(Ho Sub Lee)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 01.02.2004
• Subjects: 한의학
• ISSN: 1738-7698; 2288-2529

The persent study examined the effects of Taekunyukmijiwhang-tang (TY) on blood pressure and renal function in nitric oxide (NO)-dependent hypertensive rats. A phamacological inhibition of nitric oxide synthase (NOS) for 4-6 weeks produces renal vasoconstriction, renal dysfunction, and progressive severe hypertension. Treatment of rats with NG-Nitro-L-arginie methylester (L-NAME) (100 mg/L, 6 weeks), which is a nonspecific NOS inhibitor, cause a sustained increase in systolic blood pressure (SBP), along with the decrease in expression of ecNOS in the kidney and thoracic aorta. The expression of Na, K-ATPase α1 subunit in the kidney was also reduced in the L-NAME induced hypertensive rats group. The renal functional parameters including urine osmolality (Uosm), creatinine clearance (Ccr), which is an index of glomerular filtration (GFR) were decreased in rat with L-NAME induced hypertension. while solute-free water reabsoption (TcH2O) was unchanged in all experimenstal group. However, the group combined treated with TY and L-NAME did not develop hypertension and expression of ecNOS in the aorta was restored. The expression of Na+, K+-ATPase α1 subunit in the kidney was markedly restored in L-NAME-induced hypertension rats by administration of TY along with the restoration of urinary volume (UV) and sodium excretion (UNaV), whlie Na+, K+-ATPase β1 subunit was not altered. These results suggest that TY attenuates an increase in SBP in the L-NAME induced hypertension and restores partially renal function, which seems to be caused by up-regulation of expression of Na+, K+-ATPase α1 subunit in the kidney and ecNOS in thoracic aorta. KCI Citation Count: 1