麻黃蒲黃湯이 비만생쥐의 비만유전자 및 관련인자에 미치는 영향

• Published in: 동의생리병리학회지 Vol. 19; no. 4; pp. 1055 - 1061
• Main Authors: 송인선(In Sun Song), 송태원(Tae Won Song), 오민석(Min Suck Oh)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 01.08.2005
• Subjects: 한의학
• ISSN: 1738-7698; 2288-2529

In this study, the aim was to investigate the effect of Mahwangpohang-tang on the expression of obesity-related genes and cytokines in high fat diet induced obesity mice. In order to investigate the effects of Mahwangpohang-tang(MHPH) on the obesity-related genes and cytokines, C57BL/6 mice were fed with high fat diet. C57BL/6 mice were divided into three groups and fed for 13weeks. Body weight change, diet intake change, final increase of body weight, the ratio of the adipocyte in body weight, the expression of leptin gene in primary adipocytes, the expression of UCP-2 in primary adipocytes, the production change of TNF-α and leptin in primary adipocytes, the expression of leptin in adipocytes tissue. The body weight of Mahwangpohang-tang(MHPH) intake mice was significantly lower than high fat diet group. The amount of the adipocyte in body weight was decreased significantly. In primary adipocytes, leptin gene expression and the expression of UCP-2 did not change significantly. In primary adipocytes, the amount of TNF-α was significantly decreased at dose of 100㎍/㎖ density. In adipocytes tissue, the expression of leptin did not change significantly. These results suggest that MHPH may inhibit the expression of obesity-related genes and cytokines in high fat diet induced obesity mice KCI Citation Count: 0