관절강 내 히알루론산 주사 후 발생한 무릎 관절의 가성통풍

• Published in: The journal of the Korean Orthopaedic Association Vol. 49; no. 6; pp. 476 - 479
• Main Authors: 전호승(Ho Seung Jeon), 우영균(Young Kyun Woo), 황석하(Seok Ha Hwang), 서승표(Seung Pyo Suh), 이준경(Joon Kyung Lee)
• Format: Journal Article
• Language: Korean
• Published: 대한정형외과학회 01.12.2014
• Subjects: 정형외과학; 관절강 내 주사; knee; 히알루론산; chondrocalcinosis; 관절석회화증; intra-articular injections; 무릎; hyaluronic acid
• ISSN: 1226-2102; 2005-8918

An 82-year-old woman underwent surgery for the left intertrochanteric fracture. However, during hospitalization, she complained of pain on the right knee. Radiographs showed moderately degenerative arthritis and intrameniscal calcification. Hyaluronic acid was administered by intraarticular injection. After injection, arthritic symptoms improved. Five days after injection, she complained of severe pain, swelling, and heating sensation in the right knee with chills and fever. Blood test showed elevated white blood cell (WBC) count and C-reactive protein. WBC in synovial fluid increased to 47,250/mm3. Antimicrobial therapy was administered under the impression of acute pyogenic arthritis by adverse reaction of hyaluronic acid injection. Polarization microscope showed calcium pyrophosphate dihydrate crystals. Synovial fluid culture was negative. Finally, she was diagnosed as pseudogout. The symptoms improved within one week. To our knowledge, there has been no report of pseudogout following intraarticular injection of hyaluronic acid in Korea. Therefore, we report this case with a review of the literature. KCI Citation Count: 1