防己黃芪湯이 생쥐의 비만관련 장내분비세포와 신경펩타이드에 미치는 영향

• Published in: 동의생리병리학회지 Vol. 26; no. 4; pp. 497 - 505
• Main Authors: 김태헌(Tae Heon Kim), 김호일(Ho IL Kim), 이광규(Kwang Gyu Lee), 이상룡(Sang Ryong Lee), 이창현(Chang Hyun Lee)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 01.08.2012
• Subjects: 한의학; Obesity; Banggihwanggi-tang(BGHGT); Neuropeptide; Enteroendocrine cells
• ISSN: 1738-7698; 2288-2529

To determine the effects of Banggihwanggi-tang(BGHGT) on obesity, the obesity-related factors[gastrin, calcitonin gene related peptide(CGRP), serotonin, ghrelin, obestatin, glucagon-like peptide-1(GLP-1), insulin, orexin, leptin] were investigated in the stomach, pancreas, brain of mice by immunohistochemical(IHC) methods for 4 weeks. The change of body weight was more reduced in BGHGT administered group than that of control group. The IHC density of the gastrin and CGRP positive cells on pylorus was higher in BGHGT administered group than that of control group. The number of ghrelin immunoreactive cells on stomach was lower in BGHGT administered group than that of control group. The IHC of GLP-1 positive cells did not observe in the stomach of BGHGT administered groups. The IHC density of GLP-1 in the pancreas was lower in BGHGT administered group than that of control group. The IHC density of insulin positive cells in the pancreas was lower in BGHGT administered group than that of control group. The IHC density of orexin positive neurons in the diencephalon was slightly higher in BGHGT administered group than that of control group. The IHC density of NPY and leptin positive neurons was slightly higher in BGHGT administered group than that of control group. The IHC density of serotonin positive neurons was higher in BGHGT administered group than that of control group. Therefore, we conclude that BGHGT activates appetite inhibitor through appetite related enteroendocrine cells and neuropeptides in stomach, pancreas and brain, and this activation may also be responsible for the inhibition of feeding behavior. KCI Citation Count: 3