四君子湯合生薑汁이 정상 흰쥐의 뇌혈류역학에 미치는 기전

• Published in: 동의생리병리학회지 Vol. 21; no. 5; pp. 1271 - 1277
• Main Authors: 김거웅(Geo Woong Kim), 정현우(Hyun Woo Jeong)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 01.10.2007
• Subjects: 한의학
• ISSN: 1738-7698; 2288-2529

This study was designed to investigate the effects of Sagunja-tang Extract & Zingiberis rhizoma recens Juice (SEZJ) and Zingiberis rhizoma recens Juice (ZRJ) on the changes in regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in normal rats. The results were as follows ; SEZJ and ZRJ significantly increased rCBF in a dose-dependent manner, while it did not change MABP. This results suggest that SEZJ and ZRJ significantly increased rCBF by dilating pial arterial diameter. Increase of SEZJ-induced rCBF was significantly inhibited by pretreatment with methylene blue (10 ㎍/㎏, i.p.), an inhibitor of guanylate cyclase, and indomethacin (1 ㎎/㎏, i.p.), an inhibitor of cyclooxygenase. SEZJ-induced MABP was significantly increased by pretreatment with indomethacin but was not changed by methylene blue. These results suggested that the action of SEZJ was mediated by cyclic 3',5'-guanosine monophosphate. KCI Citation Count: 0