消渴 치료 處方 加減이 3T3-L1 Adipocytes에서 인슐린 유사성과 인슐린 민감성에 미치는 영향

• Published in: 동의생리병리학회지 Vol. 18; no. 2; pp. 451 - 456
• Main Authors: 박선민(Sun Min Park), 최미경(Mi Kyung Choi), 전동화(Dong Wha Jun), 최수봉(Soo Bong Choi), 박성규(Seong Kyu Park), 이미영(Mi Young Lee), 김호경(Ho Kyoung Kim), 황영희(Young Hee Hwang), 고병섭(Byoung-Seob Ko)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 01.04.2004
• Subjects: 한의학
• ISSN: 1738-7698; 2288-2529

Based on the data from our previous studies, four new diabetic remedies were composed with the addition of Coicis Semen into Okchun-san (OCH), Commelinae Herba into Gangsim-tang (GST), Scrophulariae Radix into Sunki-san (SKS), and Erythrinae Cortex into Yukmijihuang-hwan (YMG). The water extracts of these new remedies were treated in 3T3-L1 fibroblasts and adipocytes in order to investigate insulin-like substances and insulin sensitizers, respectively. With and without differentiation inducers, unmodified SKS (SKS-O) treatment induced 3T3-L1 fibroblasts into adipocytes more than the control. However, without inducers, YMG treatment, but not SKS, induced the differentiation more than the control among modified remedies. Without inducers, SKS, OCH as well as YMG increased the induction of differentiation from 3T3-L1 fibroblasts into adipocytes, compared to the control. The treatment of OCH and YMG with 1ng/mL insulin increased glucose uptake much more than only insulin 1 ng/mL treatment. Thus, OCH and YMG contained increased insulin actions. In conclusions, the modified remedies, OCH and YMG, contained insulin-like substances and insulin sensitizers, and they can be improved the hypoglycemic effects. KCI Citation Count: 2