안지오텐신 전환효소활성 저해에 의해 항고혈압 효과를 갖는 신품종 감자 구이밸리 추출물

• Published in: 동의생리병리학회지 Vol. 23; no. 1; pp. 93 - 96
• Main Authors: 김관현(Kwan Hyun Kim), 김선희(Sun Hee Kim), 이은옥(Eun Ok Lee), 권현정(Hyun Jung Kwon), 최종원(Jong Won Choi), 임학태(Hak Tae Lim), 김성훈(Sung Hoon Kim)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 01.02.2009
• Subjects: 한의학
• ISSN: 1738-7698; 2288-2529

This study was attempted to investigate the anti-hypertensive activity of Solanum tuberosum, cv. Gui valley. Ethanol extract of Gui vally (EGV) increased free radical scarvenge activity up to 91.6% of control at 200 ㎍/㎖. It's anti-oxidant activity is similar to 10 uM of ascorbic acid, well known as antioxidant. EGV inhibited Angiotensin-I-converting enzyme (ACE) activity in vitro. ACE plays a important role in regulation of blood pressure and ACE inhibitors are important for the treatment of hypertension. Anti-hypertensive activity of EGV in vivo was assessed in lead acetate (LAT)-induced hypertensive rats for 8 weeks. Elevated blood pressure in control group was significantly decreased by EGV at 200 mg/kg. Also, ACE activity in blood was also suppressed by EGV treatment. Taken together, these results suggest that EGV has an anti-hypersive activiy via inhibition of ACE and can be used for the treatment or prevention of hypertension. This study was attempted to investigate the anti-hypertensive activity of Solanum tuberosum, cv. Gui valley. Ethanol extract of Gui vally (EGV) increased free radical scarvenge activity up to 91.6% of control at 200 ㎍/㎖. It's anti-oxidant activity is similar to 10 uM of ascorbic acid, well known as antioxidant. EGV inhibited Angiotensin-I-converting enzyme (ACE) activity in vitro. ACE plays a important role in regulation of blood pressure and ACE inhibitors are important for the treatment of hypertension. Anti-hypertensive activity of EGV in vivo was assessed in lead acetate (LAT)-induced hypertensive rats for 8 weeks. Elevated blood pressure in control group was significantly decreased by EGV at 200 mg/kg. Also, ACE activity in blood was also suppressed by EGV treatment. Taken together, these results suggest that EGV has an anti-hypersive activiy via inhibition of ACE and can be used for the treatment or prevention of hypertension. KCI Citation Count: 0