銀翹散과 Ciprofloxacin의 병용투여가 Streptococcus pneumoniae 호흡기감염에 미치는 영향

• Published in: 동의생리병리학회지 Vol. 19; no. 4; pp. 1039 - 1045
• Main Authors: 이상준(Sang Jun Lee), 전귀옥(Kwi Ok Jeon), 송광규(Kwang Kyu Song), 최해윤(Hae Yun Choi), 김종대(Jong Dae Kim)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 01.08.2005
• Subjects: 한의학
• ISSN: 1738-7698; 2288-2529

In order to evaluate the in vivo synergic effect of Eunkyo-san which was a traditional poly-herbal formula has been used in the treatment of respiratory diseases in Korea, with quinolone antibiotics, ciprofloxacin (CPFX), the viable bacterial number and histopathological changes were monitored after experimental respiratory infection with S. pneumoniae ATCC 6303. The obtained results were as follows: In CPFX groups, the viable bacterial numbers were significantly decreased compared to that of control group and these were more dramatically decreased compared to that of single treatment with CPFX, respectively in concomitant treated groups with Eunkyo-san. In control group, severe infiltration of inflammatory cells, hemorrhage and hypertrophy of alveolar linings were demonstrated at microscopical levels. However, these abnormal histopathological changes were significantly decreased compared to that of control group in CPFX groups, and these were more dramatically decreased compared to that of single treatment with CPFX, respectively in concomitant treated groups with Eunkyo-san. In CPFX groups, the LSA (luminal surface of alveoli %) were significantly increased compared to that of control group and these were more dramatically decreased compared to that of single treatment with CPFX, respectively in concomitant treated groups with Eunkyo-san. According to these results, it is considered as the in vivo antibacterial activity of CPFX was dramatically increased by concomitant use of Eunkyo-san against S. pneumoniae ATCC 6303 infection of respiratory tract. KCI Citation Count: 4