위에 발생한 인환세포암은 미분화형에 속하는가?

• Published in: Annals of surgical treatment and research Vol. 71; no. 6; pp. 404 - 412
• Main Authors: 공필성(Pil Sung Kong), 송교영(Kyo Young Song), 임근우(Keun Woo Lim), 김승남(Seung Nam Kim), 박조현(Cho Hyun Park)
• Format: Journal Article
• Language: Korean
• Published: 대한외과학회 01.12.2006
• Subjects: 일반외과학; 위암; Pathology; Signet ring cell carcinoma; 병리; Gastric cancer; 인환세포암
• ISSN: 2288-6575; 2288-6796

Purpose: Although many studies on the clinicopathological characteristics of signet ring cell (SRC) carcinoma of the stomach have been made, there is no consistent report of the characteristics and prognosis of this condition. In this study, the clinicopathological features and prognosis of patients with SRC and non-SRC gastric cancer were compared. Methods: Between 1990 and 2002, 1,884 patients, who underwent a curative resection for gastric cancer in our hospital, were analyzed retrospectively. Among them, 185 (9.8%) patients with SRC were compared with 1,699 (90.2%) patients with non-SRC. Results: SRC in gastric cancer was found more commonly in younger patients and women. The depth of the invasion in the SRC patients was less invasive and a lymph node metastasis is less frequent. A higher frequency of the depressed gross type and middle third tumor location in SRC are similar characteristics of the undifferentiated type of gastric cancer. However, SRC in EGC have similar characteristics to the differentiated type of gastric cancer such as a higher rate of mucosa-confined tumors and less frequent lymph node metastasis. The five-year survival rate of SRC in AGC was similar to that of other pathologic types, and the pathologic type does not influence the survival rate. Conclusion: SRC patient in EGC should be considered as a differentiated type. Therefore, the mucosa confined tumor and less frequent lymph node metastases are expected. (J Korean Surg Soc 2006;71:404-412) KCI Citation Count: 1