위암의 악성도와 Tumor Necrosis Factor-α Promoter 다형성의 연관성

• Published in: Annals of surgical treatment and research Vol. 68; no. 4; pp. 288 - 295
• Main Authors: 김운원(Woon Won Kim), 홍관희(Kwan Hee Hong), 장원희(Won Hee Jang), 김형인(Hyeong-In Kim), 서지연(Ji Yeon Seo), 양영일(Young-Il Yang)
• Format: Journal Article
• Language: Korean
• Published: 대한외과학회 01.04.2005
• Subjects: 일반외과학; Progression; 진행성 위암; Promoter polymorphism; TNF-α; Gastric cancer; Promoter 다형성
• ISSN: 2288-6575; 2288-6796

Purpose: The pro-inflammatory cytokine, tumor necrosis factor-α (TNF-α), is a central mediator of the immune response involved in a wide range of immuno-inflammatory and infectious diseases. There is increasing evidence that TNF-α may promote the development and spread of the cancer. Polymorphisms in the TNF-α promoter have been related to TNF-α production. Therefore, we investigated the potential association of TNF-α genotypes with gastric cancer in the Korean population. Methods: The study included 66 patients with gastric adenoma, 75 patients with gastric carcinoma, and 551 healthy controls. The -308 and -238 polymorphisms in the TNF-α promoter were analyzed by PCR- restriction fragment length polymorphism (RFLP). Distributions of TNF-α promoter polymorphisms were compared between groups byχ2 test. P values smaller than 0.05 were considered to be significant. Results: The proportion of individuals carrying the TNF-α -308A allele was higher in the carcinoma group compared to controls and adenomas, but the differences were not significant (P=0.124). However, the TNF-α -308A allele was significantly associated with advanced gastric carcinoma (P=0.026), serosa invasion (P=0.004), neural invasion (P= 0.021), and lymph node metastasis (P=0.005). On the other hand, the TNF-α -238G/A polymorphism was not associated with the development of gastric adenoma and carcino ma and the severity of gastric carcinoma. Conclusion: These results suggest that the TNF-α -308A allele is associated with the severity of gastric carcinoma in terms of invasion and metastasis in the Korean population. Therefore, TNF-α promoter polymorphism could be used as a predictive marker of the severity of gastric carcinoma. KCI Citation Count: 0