유두상 갑상선암에서 종양의 크기에 따른 중앙 경부림프절 전이 및 이와 관련된 인자에 대한 비교분석

• Published in: Annals of surgical treatment and research Vol. 75; no. 3; pp. 156 - 161
• Main Authors: 이관주(Kwan Ju Lee), 김형래(Hyung Rae Kim), 김세준(Say June Kim), 이상철(Sang Chul Lee), 김정구(Jeong Goo Kim), 성기영(Gi Young Sung), 박우찬(Woo Chan Park), 오세정(Se Jeong Oh), 안창준(Chang Joon Ahn), 이동호(Dong Ho Lee)
• Format: Journal Article
• Language: Korean
• Published: 대한외과학회 01.09.2008
• Subjects: 일반외과학; 중앙 경부림프절; Central cervical lymph node; 유두상 갑상선암; 유두상 갑상선 미세암; Tumor size; 종양크기; Papillary thyroid microcarcinoma; Papillary thyroid carcinoma
• ISSN: 2288-6575; 2288-6796

Purpose: The aim of this study was to analyze the relationship between central lymph node metastasis and the associated factors in patients with papillary thyroid carcinoma (PTC) according to the tumor size, and we wanted to determine an appropriate treatment for PTC. Methods: From June 2005 to May 2007, 218 patients with PTC underwent total thyroidectomy or lobectomy, and they also received central lymph node dissection at our institution. The patients were divided into three groups: group 1 (tumor ≤5 mm), group 2 (5 mm＜tumor≤10 mm), and group 3 (tumor＞10 mm). We retrospectively reviewed these patients to analyze the relationship between tumor size and the clinicopathological characteristics, including age, gender, lymph node metastasis, extrathyroidal extension, capsular invasion and lymphovascular invasion. Results: There were 47 (21.6%) patients in group 1, 101 (46.3%) patients in group 2 and 70 (32.1%) patients in group 3. The tumor size was closely correlated with the presence of extrathyroidal extension, capsular invasion and lymph node metastasis (P＜0.001). Lymph node metastasis was not only closely correlated with tumor size, but it was also significantly associated with extrathyroidal extension, capsular invasion and lymphovascular invasion (P＜0.05). Conclusion: Our study confirmed that some factors, including central lymph node metastasis, capsular invasion and extrathyroidal extension, were frequently observed in patients with papillary thyroid microcarcinoma (PTMC), and central lymph node metastasis was related to tumor size, extrathyroidal extension, capsular invasion and lymphovascular invasion. Therefore, routine central lymph node dissection is recommended during the initial surgery for patients with PTMC. (J Korean Surg Soc 2008;75:156-161) KCI Citation Count: 2