유방의 침윤성 관암종에서 EGFR, c-erbB-2 유전자 증폭과 COX-2 단백 발현의 연관성

• Published in: Annals of surgical treatment and research Vol. 69; no. 4; pp. 279 - 285
• Main Authors: 홍범기(Beom Ki Hong), 김범규(Beom Gyu Kim), 차성재(Sung Jae Cha), 박성준(Sung Jun Park), 임현묵(Hyun Muck Lim), 이태진(Tae Jin Lee)
• Format: Journal Article
• Language: Korean
• Published: 대한외과학회 01.10.2005
• Subjects: 일반외과학; 유방암; Breast cancer; 표피성장인자 수용체; COX-2; c-erbB-2; EGFR
• ISSN: 2288-6575; 2288-6796

Purpose: Abnormalities of epidermal growth factor receptor (EGFR) and c-erbB-2 have been actively investigated in breast cancer. Cyclooxygenase-2 (COX-2) seems to be involved in critical steps of cancer onset and progression. The purpose of this study is to determine the correlation between the gene ampilfications of the EGFR and c-erbB-2 and expression of the COX-2. Methods: Using Chromogenic in situ Hybridization (CISH) the gene amplification of the EGFR and c-erbB-2 were studies on paraffin sections of 47 invasive ductal carcinomas. The expression of COX-2 was studied immunohistochemically (IHC). Results: Of the 47 invasive duct carcinomas, gene amplifications of the EGFR and c-erbB-2 by CISH were observed in 21 cases (44.7%) and 14 cases (29.8%), respectively. The gene amplification of EGFR was significantly correlated with tumor size, nodal metastasis, and stage. The gene amplification of c-erbB-2 showed a statistically significant correlation with tumor size and stage. The protein of COX-2 was expressed by IHC in 30 cases (63.8%). The expression of the COX-2 protein showed a statistically significant correlation with tumor size, nodal metastasis, and stage. The gene amplifications of the EGFR and c-erbB-2 between expression of COX-2 protein showed a statistically significant correlation. Conclusion: The gene amplification of the EGFR and c- erbB-2 may be correlated with expression of COX-2 protein in the breast cancer. KCI Citation Count: 0