Plasmid-based transgenic mouse model for studying in vivo mutations

A new transgenic mouse model for studying in vivo somatic mutations is based on the efficient recovery of chromosomally integrated lacZ-containing plasmids, using magnetic beads.

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Bibliographic Details
Published inNature (London) Vol. 377; no. 6550; pp. 657 - 659
Main Authors Boerrigter, Michaël E. T. I, Dollé, Martijn E. T, Martus, Hans-Jörg, Gossen, Jan A, Vijg, Jan
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 19.10.1995
Subjects
Animals
Bacteriophage lambda - genetics
Deoxyribonucleic acid
DNA
Lac Operon
Mice
Mice, Inbred C57BL
Mice, Transgenic
Models, Genetic
Mutation
Plasmids
Rodents
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Summary:A new transgenic mouse model for studying in vivo somatic mutations is based on the efficient recovery of chromosomally integrated lacZ-containing plasmids, using magnetic beads.
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ISSN:0028-0836
1476-4687
DOI:10.1038/377657a0