Gender affects reperfusion injury in rat liver

Sex mismatch is a well-known risk factor for chronic rejection of liver allografts, but the mechanisms involved remain unclear. Since experimental observations suggest that female liver is more sensitive to reperfusion injury than male liver, we assessed the influence of gender on oxidative stress....

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Published inDigestive diseases and sciences Vol. 46; no. 6; pp. 1305 - 1312
Main Authors GASBARRINI, Antonio, ADDOLORATO, Giovanni, DI CAMPLI, Cristiana, SIMONCINI, Mara, MONTEMAGNO, Salvatore, CASTAGNETO, Marco, PADALINO, Cristiano, POLA, Paolo, GASBARRINI, Giovanni
Format Journal Article
LanguageEnglish
Published Heidelberg Springer 01.06.2001
Springer Nature B.V
Subjects
Animals
Biological and medical sciences
Female
Gastroenterology. Liver. Pancreas. Abdomen
Liver Diseases - etiology
Liver Diseases - pathology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Luminescent Measurements
Male
Medical sciences
Other diseases. Semiology
Rats
Rats, Wistar
Reperfusion Injury - etiology
Reperfusion Injury - pathology
Sex Factors
Rat
Liver
Rodentia
Sex
Cardiovascular disease
Hepatic disease
Epidemiology
Vascular disease
Vertebrata
Mammalia
Reperfusion
Ischemia
Animal
Predisposition
Digestive diseases
Severity score
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Summary:Sex mismatch is a well-known risk factor for chronic rejection of liver allografts, but the mechanisms involved remain unclear. Since experimental observations suggest that female liver is more sensitive to reperfusion injury than male liver, we assessed the influence of gender on oxidative stress. Livers from male and female rats were exposed to warm ischemia and reperfused by an oxygenated buffer. Chemiluminescence was continuously recorded. Reduced and oxidized glutathione and malondialdehyde lactic dehydrogenase values were also determined. Chemiluminescence increased during reperfusion in both groups, but was significantly greater in livers from female rats. Malondyaldehyde and lactic dehydrogenase progressively increased in all animals, reaching significantly greater values in female rats. Livers from female rats showed an increase in all the parameters of oxidative stress compared to male animals. A greater susceptibility to reperfusion injury may be evoked as an alternative mechanism to explain the poor outcome of female organ after liver transplantation.
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ISSN:0163-2116
1573-2568
DOI:10.1023/a:1010679716435