Successful cord blood transplantation for mycosis fungoides

A 26-year-old female diagnosed as mycosis fungoides (MF, clinical stage IV) was treated with single-agent chemotherapy, multi-drug chemotherapy and unrelated bone marrow transplantation with reduced-intensity conditioning (engraftment failure), resulting in failure. Unrelated cord blood transplantat...

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Bibliographic Details
Published inInternational journal of hematology Vol. 88; no. 5; pp. 596 - 598
Main Authors Fukushima, Takuya, Horio, Kensuke, Matsuo, Emi, Imanishi, Daisuke, Yamasaki, Reishi, Tsushima, Hideki, Imaizumi, Yoshitaka, Ohshima, Koichi, Hata, Tomoko, Yoshida, Shinichiro, Miyazaki, Yasushi, Tomonaga, Masao
Format Journal Article
LanguageEnglish
Published Tokyo Springer Japan 01.12.2008
Springer Nature B.V
Subjects
Adult
Bone Marrow Transplantation
Case Report
Cord Blood Stem Cell Transplantation
Female
Graft vs Tumor Effect
Hematology
Humans
Medicine
Medicine & Public Health
Mycosis Fungoides - pathology
Mycosis Fungoides - therapy
Oncology
Recurrence
Skin Neoplasms - pathology
Skin Neoplasms - therapy
Transplantation Conditioning
Transplantation, Homologous
Mycosis fungoides
Graft-versus-lymphoma effect
Cord blood transplantation
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Summary:A 26-year-old female diagnosed as mycosis fungoides (MF, clinical stage IV) was treated with single-agent chemotherapy, multi-drug chemotherapy and unrelated bone marrow transplantation with reduced-intensity conditioning (engraftment failure), resulting in failure. Unrelated cord blood transplantation (CBT) as second transplantation following myeloablative conditioning brought complete remission (CR), but relapse of MF occurred 3 months after transplantation. However, discontinuation of immune suppressant led to the regression of MF regions and to second CR that continued for more than 23 months. This is the first report of successful CBT for MF, suggesting the graft-versus-MF effect in a setting of CBT.
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ISSN:0925-5710
1865-3774
DOI:10.1007/s12185-008-0190-4