Isolation of hemorrhagic fever with renal syndrome (HFRS) virus from a tumor specimen in a rat

A strain of hemorrhagic fever with renal syndrome (HFRS) virus was isolated in a cell culture from a tumor specimen in a rat kept in a medical institution in which there was a case of HFRS. Positive immunofluorescent reaction with sera from HFRS patients was recognized at the second passage and the...

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Bibliographic Details
Published inBiken journal Vol. 26; no. 4; p. 155
Main Authors Yamanishi, K, Dantas, J R, Takahashi, M, Yamanouchi, T, Domae, K, Kawamata, J, Kurata, T
Format Journal Article
LanguageEnglish
Published Japan 01.12.1983
Subjects
Animals
Antibodies, Viral - analysis
Antigens, Viral - analysis
Cell Line
Female
Fibroma - microbiology
Fluorescent Antibody Technique
Hantavirus - immunology
Hantavirus - isolation & purification
Hemorrhagic Fever with Renal Syndrome - immunology
Humans
Neoplasm Transplantation
Rats
RNA Viruses - isolation & purification
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Summary:A strain of hemorrhagic fever with renal syndrome (HFRS) virus was isolated in a cell culture from a tumor specimen in a rat kept in a medical institution in which there was a case of HFRS. Positive immunofluorescent reaction with sera from HFRS patients was recognized at the second passage and the number of cells containing antigen increased in the third passage. This virus, named B-1 strain, was identified as the HFRS virus by immunofluorescent tests with sera from patients.
ISSN:0006-2324