No increased risk of thrombosis in heterozygous congenital dysplasminogenemia

To assess the risk of thrombosis in congenital dysplasminogenemia, we studied 10 unrelated families with this disorder. The probands were excluded from the analysis of data to prevent bias in the selection of subjects. Positive thrombotic histories were found in 1 of the 25 family members determined...

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Bibliographic Details
Published inInternational journal of hematology Vol. 72; no. 2; p. 247
Main Authors Shigekiyo, T, Kanazuka, M, Aihara, K, Azuma, H, Ohshima, Y, Horie, H, Nakahira, H, Takeichi, T, Matsumoto, T
Format Journal Article
LanguageEnglish
Published Japan 01.08.2000
Subjects
Adolescent
Adult
Aged
Aged, 80 and over
Amino Acid Substitution
Family Health
Female
Heterozygote
Humans
Male
Middle Aged
Mutation
Pedigree
Plasminogen - deficiency
Plasminogen - genetics
Polymorphism, Restriction Fragment Length
Risk Factors
Thrombosis - etiology
Thrombosis - genetics
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Summary:To assess the risk of thrombosis in congenital dysplasminogenemia, we studied 10 unrelated families with this disorder. The probands were excluded from the analysis of data to prevent bias in the selection of subjects. Positive thrombotic histories were found in 1 of the 25 family members determined to have heterozygous congenital dysplasminogenemia and in 2 of their 41 biochemically unaffected relatives. The percentages of family members with no history of thrombosis up to a given age among subjects with and without congenital dysplasminogenemia were analyzed by the Kaplan-Meier method. No significant difference between the 2 groups was observed by generalized Wilcoxon test (P = .32) or Cox-Mantel test (P = .62). These findings suggest that heterozygous congenital dysplasminogenemia is not associated with an increased risk of thrombosis.
ISSN:0925-5710