Cytotoxic constituents from the whole plant of Corydalis pallida

Here we report the cytotoxic activity of three known compounds isolated for the first time from Corydalis pallida (Papaveraceae). An isoquinoline alkaloid, berberine, exhibited cytototoxic activity against two human cancer cell lines, HT-1080 (human fibrosarcoma) and SNU-638 (human stomach adenocarc...

Full description

Saved in:
Bibliographic Details
Published inArchives of pharmacal research Vol. 28; no. 11; pp. 1224 - 1227
Main Authors Kim, Hyang Rim, Min, Hye-Young, Jeong, Yeon Hee, Lee, Sang Kook, Lee, Nam Sook, Seo, Eun-Kyoung
Format Journal Article
LanguageEnglish
Published Korea (South) 대한약학회 01.11.2005
Subjects
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
Berberine - pharmacology
Cell Line, Tumor
Cell Survival - drug effects
Corydalis - chemistry
Drug Screening Assays, Antitumor
Humans
Indicators and Reagents
Magnetic Resonance Spectroscopy
약학
Online AccessGet full text

Cover

More Information
Summary:Here we report the cytotoxic activity of three known compounds isolated for the first time from Corydalis pallida (Papaveraceae). An isoquinoline alkaloid, berberine, exhibited cytototoxic activity against two human cancer cell lines, HT-1080 (human fibrosarcoma) and SNU-638 (human stomach adenocarcinoma), with IC50 values of 3.2 and 3.4 microg/mL, respectively. N-trans-feruloyltyramine and N-trans-feruloylmethoxytyramine were also isolated from this plant but were inactive.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
G704-000010.2005.28.11.006
ISSN:0253-6269
1976-3786
DOI:10.1007/bf02978202