Cytotoxic terpenes and lignans from the roots of Ainsliaea acerifolia

• Published in: Archives of pharmacal research Vol. 29; no. 3; pp. 203 - 208
• Main Authors: Choi, Sang Zin, Yang, Min Cheol, Choi, Sang Un, Lee, Kang Ro
• Format: Journal Article
• Language: English
• Published: Korea (South) 대한약학회 01.03.2006
• Subjects: Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Asteraceae - chemistry; Cell Line, Tumor; Cell Proliferation - drug effects; Humans; Inhibitory Concentration 50; Lignans - chemistry; Lignans - isolation & purification; Lignans - pharmacology; Oleanolic Acid - analogs & derivatives; Oleanolic Acid - chemistry; Oleanolic Acid - isolation & purification; Oleanolic Acid - pharmacology; Plant Roots - chemistry; Sesquiterpenes - chemistry; Sesquiterpenes - isolation & purification; Sesquiterpenes - pharmacology; Sesquiterpenes, Guaiane; Triterpenes - chemistry; Triterpenes - isolation & purification; Triterpenes - pharmacology; 약학
• ISSN: 0253-6269; 1976-3786
• DOI: 10.1007/BF02969394

The chromatographic separation of the MeOH extract of the roots of Ainsliaea acerifolia (Compositae) led to the isolation of six known terpenes and two known lignans. Their structures were identified by spectroscopic methods as mokko lactone (1), betulonic acid (2), betulinic acid (3), zaluzanin C (4), 1beta-hydroperoxygermacra-4(15),5,10(14)-triene (5), pluviatilol (6), (+)-syringaresinol (7), and glucozaluzanin C (8). Compounds 1 approximately 4 and 8 showed non-specific significant cytotoxicity against five human tumor cell lines with ED50 values ranging from 0.36 approximately 5.54 microg/mL.