Anti-inflammatory activity of flavonoids from Populus davidiana

• Published in: Archives of pharmacal research Vol. 29; no. 12; pp. 1102 - 1108
• Main Authors: Zhang, XinFeng, Hung, Tran Manh, Phuong, Phuong Thien, Ngoc, Tran Minh, Min, Byung-Sun, Song, Kyung-Sik, Seong, Yeon Hee, Bae, KiHwan
• Format: Journal Article
• Language: English
• Published: Korea (South) 대한약학회 01.12.2006
• Subjects: Anti-Inflammatory Agents, Non-Steroidal - isolation & purification; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Cyclooxygenase 1 - metabolism; Cyclooxygenase 2 Inhibitors - isolation & purification; Cyclooxygenase 2 Inhibitors - pharmacology; Cyclooxygenase Inhibitors - isolation & purification; Cyclooxygenase Inhibitors - pharmacology; Enzyme Inhibitors - pharmacology; Flavonoids - isolation & purification; Flavonoids - pharmacology; Hydrolysis; Magnetic Resonance Spectroscopy; Plant Bark - chemistry; Plant Extracts - analysis; Populus - chemistry; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Superoxides - metabolism; Xanthine Oxidase - antagonists & inhibitors; 약학
• ISSN: 0253-6269; 1976-3786
• DOI: 10.1007/BF02969299

An in vitro bioassay-guide revealed that the methanol (MeOH) extract of the stem bark of Populus davidiana showed considerable inhibitory activity against cyclooxygenase (COX-1, COX-2). Continuous phytochemical study of the MeOH extract of this plant led to the isolation of ten flavonoids; sakuranetin (1), rhamnocitrin (2), 7-O-methylaromadendrin (3), naringenin (4), eriodictyol (5), aromadendrin (6), kaempferol (7), neosakuranin (8), sakuranin (9) and sakurenetin-5,4'-di-beta-D-glucopyranoside (10). Their structures were identified on the basis of their physicochemical and spectroscopic analyses. The isolated compounds, 1-10, were tested for their inhibitory activities against COX-1 and COX-2. Compound 7 was found to have potent inhibitory effect on COX-1 and a moderate effect on COX-2, meanwhile, compounds 1-6 showed moderate inhibition against COX-1 only. Moreover, compounds 5-8 exhibited suppressive effects on xanthine oxidase (XO). These results may explain, in part, the traditional uses of P. davidiana in ethnomedicine.