Treatment of exudative fibrinous pericarditis with intrapericardial urokinase

Three male patients with purulent pericarditis, in whom complete drainage could not be obtained by pericardiocentesis, were treated with transcatheter intrapericardial urokinase to prevent the development of chronic constrictive pericarditis. As shown by echocardiography, the intrapericardial fibrin...

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Bibliographic Details
Published inThe Lancet (British edition) Vol. 344; no. 8936; pp. 1541 - 1542
Main Authors WINKLER, W.-B, KARNIK, R, SLANY, J
Format Journal Article
LanguageEnglish
Published London Lancet 03.12.1994
Elsevier Limited
Subjects
Adult
Biological and medical sciences
Cardiovascular disease
Cardiovascular system
Drainage
Drug therapy
Echocardiography
Fibrinolysis
Humans
Male
Medical research
Medical sciences
Middle Aged
Miscellaneous
Pericarditis - drug therapy
Pericarditis, Constrictive - prevention & control
Pharmacology. Drug treatments
Urokinase-Type Plasminogen Activator - administration & dosage
Infection
Case study
Human
Bacterial pericarditis
Chemotherapy
Treatment
Heart disease
Bacteriosis
Cardiovascular disease
Intracardiac administration
Fibrinolytic
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Summary:Three male patients with purulent pericarditis, in whom complete drainage could not be obtained by pericardiocentesis, were treated with transcatheter intrapericardial urokinase to prevent the development of chronic constrictive pericarditis. As shown by echocardiography, the intrapericardial fibrin layers disappeared in two cases and were reduced by more than half in the third. Effects on systemic coagulation indices and complications related to intrapericardial lysis were not observed.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
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ISSN:0140-6736
1474-547X
DOI:10.1016/s0140-6736(94)90352-2