Comparison of Matrices for Optimal Analysis of Synthetic Polymers Using MALDI-TOF Mass Spectrometry

• Published in: Mass spectrometry letters Vol. 11; no. 4; pp. 77 - 81
• Main Authors: Hee-Jin Yoo, Duck-Hyun Kim, Yoon-Ji Choi, Jung Hoon Choi, Moonhee Park, DongJin Shin, YoonSeok Oh, YangSun Kim, Kun Cho
• Format: Journal Article
• Language: English
• Published: 한국질량분석학회 01.12.2020; 사단법인 한국질량분석학회
• Subjects: 화학; synthetic polymer; MALDI-TOF MS; 2,5-DHB; CHCA; dithranol
• ISSN: 2233-4203; 2093-8950
• DOI: 10.5478/MSL.2020.11.4.77

Characterization of the various chemical aspects of composite polymers is important for quality control of manufac- tured polymers. In this study, we compared three suitable matrices (α cyano-4-hydroxycinnamic acid [CHCA], 2,5 dihydroxy benzoic acid [2,5-DHB], and dithranol), to characterize various synthetic polymers by matrix-assisted laser desorption/ioniza- tion time-of-flight mass spectrometry. Although the spectra obtained with the CHCA and 2,5-DHB matrices were generally good, in certain samples ghost peaks disappeared only when dithranol was used as the matrix. Furthermore, we examined the use of sodium trifluoroacetate (NaTFA) as an additive to reduce interference by metals and copolymers in the spectra. In conclusion, appropriate selection of a matrix, according to the characteristics of the polymer, and the use of additives to improve sensitivity are important considerations for polymer analysis and development. KCI Citation Count: 0