Surface Modification of Polyurethane Using Sulfonated PEG Grafted Polyrotaxane for Improved Biocompatibility

• Published in: Macromolecular research Vol. 14; no. 1; pp. 73 - 80
• Main Authors: Hyung Dal Park, Jin Woo Bae, Ki Dong Park, Tooru Ooya, Nobuhiko Yui, Jun Hyeog Jang, Dong Keun Han, Jung Woog Shin
• Format: Journal Article
• Language: English
• Published: 한국고분자학회 01.02.2006
• Subjects: 고분자공학; protein adsorption; sulfonated polyethylene glycol; biocompatible; polyrotaxane; anticoagulant activity
• ISSN: 1598-5032; 2092-7673
• DOI: 10.1007/BF03219071

Sulfonated poly(ethylene glycol) (PEG-SO3) grafted polyrotaxanes (PRx-PEG-SO3) were prepared in order to utilize the unique properties of PEG-SO3 and the supramolecular structure of PRx, in which PEG-SO3 grafted -cyclodextrins (-CDs) were threaded onto PEG segments in a PEG-b-poly(propylene glycol) (PPG)-b-PEG triblock copolymer (Pluronic) chain capped with bulky end groups. Some of the PRx-PEG-SO3 demonstrated a higher anticoagulant activity in case of PRx-PEG-SO3 (P105), and compared with the control they showed a lower fibrinogen adsorption in PRx-PEG-SO3 (F68) and a higher binding affinity with fibroblast growth factor. The obtained results suggested that polyrotaxane incorporated with PEG-SO3 may be applicable to the surface modifi cation of clinically used polymers, especially for blood/cell compatible medical devices. KCI Citation Count: 19