Antiprotozoal activity of deacetylated chitosan oligosaccharide (dp 2-8) on Trichomonas vaginalis

Deacetylated chitosan oligosaccharide (COS) hadeffective antiprotozoal activity against Trichomonas vaginalis(Minimal Inhibitory Concentration, MIC 0.25%), whereas80% acetylated COS showed no antiprotozoal activity (MIC>1%). On the other hand, 80% acetylated COS showedgrowth stimulatory activity...

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Published inJournal of microbiology and biotechnology Vol. 16; no. 12; pp. 1984 - 1989
Main Authors SHIN, Woon-Seob, KIL, Jun-Cheul, PARK, Gab-Man
Format Journal Article
LanguageEnglish
Published Seoul Korean Society for Applied Microbiology 01.12.2006
한국미생물·생명공학회
Subjects
Biological and medical sciences
Biotechnology
Fundamental and applied biological sciences. Psychology
생물학
Trichomonas vaginalis
Protozoa
chitosan oligosaccharide
Oligosaccharide
Trichomonadida
Chitosan
antitrichomonal agent
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ISSN1017-7825

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Summary:Deacetylated chitosan oligosaccharide (COS) hadeffective antiprotozoal activity against Trichomonas vaginalis(Minimal Inhibitory Concentration, MIC 0.25%), whereas80% acetylated COS showed no antiprotozoal activity (MIC>1%). On the other hand, 80% acetylated COS showedgrowth stimulatory activity against the protozoa. When T.vaginalisconcentration, the viability of the protozoa was rapidly decreasedwithin 15 min, and the protozoa completely died within40 min. Ultrastructural changes of trichomonads treated withCOS included a los of defined nuclear membrane andendoplasmic reticulum membranes, an increase in the numberof free ribosome, vacuolation, and ultimately lysis of the celmembrane. These results indicate that deacetylated COScan be used as an antitrichomonal agent, although its lethalmechanism is not known. KCI Citation Count: 5
Bibliography:G704-000169.2006.16.12.008
ISSN:1017-7825