Development of an in-vitro circulatory system with known resistance and capacitance

An in-vitro (hydrodynamic) model of the circulatory system was developed. The model consisted of a pump, compliant tubing, and valves for resistance. The model is used to simulate aortic pressure and flow. These parameters were measured using a Konigsburg Pressure transducer and a Triton ART2 flow p...

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Bibliographic Details
Published inBiomedical sciences instrumentation Vol. 32; p. 183
Main Authors Offerdahl, C D, Schaub, J D, Koenig, S C, Swope, R D, Ewert, D L
Format Journal Article
LanguageEnglish
Published United States 1996
Subjects
Animals
Aorta - physiology
Compliance
Macaca mulatta
Models, Cardiovascular
Vascular Resistance
Venous Pressure
NASA Discipline Cardiopulmonary
Non-NASA Center
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Summary:An in-vitro (hydrodynamic) model of the circulatory system was developed. The model consisted of a pump, compliant tubing, and valves for resistance. The model is used to simulate aortic pressure and flow. These parameters were measured using a Konigsburg Pressure transducer and a Triton ART2 flow probe. In addition, venous pressure and flow were measured on the downstream side of the resistance. The system has a known compliance and resistance. Steady and pulsatile flow tests were conducted to determine the resistance of the model. A static compliance test was used to determine the compliance of the system. The aortic pressure and flow obtained from the hydrodynamic model will be used to test the accuracy of parameter estimation models such as the 2-element and 4-element Windkessel models and the 3-element Westkessel model. Verifying analytical models used in determining total peripheral resistance (TPR) and systemic arterial compliance (SAC) is important because it provides insight into hemodynamic parameters that indicate baroreceptor responsiveness to situations such as changes in gravitational acceleration.
ISSN:0067-8856