Intercellular adhesion molecule-I (ICAM-I) expression correlated to inflammation

• Published in: British journal of dermatology (1951) Vol. 120; no. 4; p. 479
• Main Authors: Lisby, S, Ralfkiaer, E, Rothlein, R, Vejlsgaard, G L
• Format: Journal Article
• Language: English
• Published: England 01.04.1989
• Subjects: Antigens, Surface - analysis; Cell Adhesion Molecules; Epidermis - immunology; Epidermis - pathology; HLA-DR Antigens - analysis; Humans; Keratins; Psoriasis - drug therapy; Psoriasis - immunology; PUVA Therapy; Time Factors
• ISSN: 0007-0963
• DOI: 10.1111/j.1365-2133.1989.tb01320.x

The presence of intercellular adhesion molecule-I (ICAM-I) on keratinocytes of psoriatic skin lesions before and during 8-methoxapsoralen and UVA light (PUVA) treatment was studied. ICAM-I was expressed on the keratinocytes in biopsies of the skin lesions of five patients with psoriasis. The patients who responded to PUVA treatment had a concurrent reduction of ICAM-I expression on the keratinocytes with a reduction of the number of cells in the mononuclear cellular infiltrate and a lessening of the severity of the disease. Patients who went into remission during therapy and then relapsed showed an increase in ICAM-I expression on keratinocytes with an increase in the number of cells in the mononuclear cell infiltrate and an increase in the severity of the disease. HLA-DR expression on keratinocytes was variable during treatment and showed no strong correlation with disease severity.