Kinetic modeling of submerged culture of A. blazei with mixed carbon sources of glucose and dextrin

• Published in: Journal of microbiology and biotechnology Vol. 16; no. 9; pp. 1331 - 1337
• Main Authors: NA, Jeong-Geol, HYUN HAN KIM, YONG KEUN CHANG, SANG JONG LEE
• Format: Journal Article
• Language: English
• Published: Seoul Korean Society for Applied Microbiology 01.09.2006; 한국미생물·생명공학회
• Subjects: Biological and medical sciences; Biotechnology; Fundamental and applied biological sciences. Psychology; 생물학; Fungi; Mechanistic model; Kinetic model; Agaricus; Submerged culture; mixed carbon sources; Basidiomycetes; Glucose; Thallophyta; Agaricus blazei
• ISSN: 1017-7825

A mathematical model has ben proposed for thebatch culture of Agaricus blazei with mixed carbon sources ofof A. blazei was divided into three parts: cel growth,exopolysaccharides (EPS) production, and another EPSproduction pathway activated by dextrin hydrolysis. Eachpathway was described mathematically and incorporatedinto the mechanistic model structure. Batch cultures werecarried out with six diferent carbon source compositions.Although parameters were estimated by using the experimentaldata from the two extreme cases such as glucose onlyof glucose, cell mas, and EPS concentrations for al thesix diferent carbon source mixtures, showing a goodinterpolation capability. Of note, the lag in EPS productioncould be quite precisely predicted by assuming that theglucose-to-cell mas ratio was the governing factor for EPSproduction. KCI Citation Count: 1