Inhibitory Effect of the Ethyl Acetate Fraction from Tulip Tree Leaf (Liriodendron tulipifera L.) on Adipogenesis in 3T3-L1 Cells

The inhibitory effects of adipogenesis on ethyl acetate (EtOAc) fraction from leaves of the Tulip tree (TT) were evaluated. Exposure to TT EtOAc fraction (25~200 mg/mL) for a 72 hr incubation period did not significantly change cell viability. TT EtOAc fraction, with concentrations of 100 and 200 mg...

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Bibliographic Details
Published inNatural product sciences Vol. 19; no. 3; pp. 263 - 268
Main Authors Ha Jin Nam, Harry Jung, Jin Kyu Kim, Jun Gyo Suh
Format Journal Article
LanguageEnglish
Published 한국생약학회 2013
Subjects
약학
3T3-L1 cells
C/EBPα
Tulip tree
Anti-obesity
PPARγ
Adipogenesis
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Summary:The inhibitory effects of adipogenesis on ethyl acetate (EtOAc) fraction from leaves of the Tulip tree (TT) were evaluated. Exposure to TT EtOAc fraction (25~200 mg/mL) for a 72 hr incubation period did not significantly change cell viability. TT EtOAc fraction, with concentrations of 100 and 200 mg/mL, inhibited lipid accumulation in 3T3-L1 adipocytes in a dose dependent manner in adipogenesis. The expression of PPARg and C/EBPa, essential adipogenic markers, was significantly decreased when TT EtOAc fraction was added to cells for 8 days as compared with the untreated control group. These results suggest that TT EtOAc fraction might be a potential therapeutic agent as an effective, natural alternative material for obesity treatment. KCI Citation Count: 0
Bibliography:G704-001403.2013.19.3.001
ISSN:1226-3907
2288-9027