Detection of Integrons and Staphylococcal Cassette Chromosome mec Types in Clinical Methicillinresistant Coagulase Negative Staphylococci Strains

• Published in: Osong public health and research perspectives pp. 47 - 53
• Main Authors: Fahimeh Hajiahmadi, Elham Salimi Ghale, Mohammad Yousef Alikhani, Alireza Mordadi, Mohammad Reza Arabestani
• Format: Journal Article
• Language: English
• Published: 질병관리본부 01.02.2017
• Subjects: 예방의학
• ISSN: 2210-9099; 2233-6052
• DOI: 10.24171/j.phrp.2017.8.1.06

Objectives: Integrons are thought to play an important role in the spread of antibiotic resistance. This study investigates class 1 and 2 integron-positive methicillin-resistant coagulase-negative staphylococci strains isolated in Iran and characterizes their patterns of antimicrobial resistance. Methods: Hundred clinical isolates of coagulase-negative staphylococci were characterized for integron content and staphylococcal cassette chromosome mec (SCCmec) type. Results: Sixteen isolates carried class 1 (intI1) integrons and four isolates carried class 2 (intI2) integrons. One resistance gene array was identified among the class 1 integrons (aadA1 cassette). The distribution of SCCmec types in 50 methicillin-resistant coagulase-negative staphylococci strains showed that SCCmec types III and V dominated among the tested strains. Conclusion: This is the first report of methicillin-resistant coagulase-negative staphylococci strains that carry two mobile genetic elements, including class 1 and 2 integrons and SCCmec, in Iran. KCI Citation Count: 0