Evaluation of GENESIS-BCPTM Scaffold Composed of Hydroxyapatite and β-Tricalcium Phosphate on Bone Formation

• Published in: Macromolecular research pp. 627 - 633
• Main Authors: 양대혁, 권일근, 박하나, 배민수, 이정복, 허동녕, 이원준, 박영민, 조영환, 김덕수
• Format: Journal Article
• Language: English
• Published: 한국고분자학회 01.06.2012
• Subjects: 고분자공학
• ISSN: 1598-5032; 2092-7673
• DOI: 10.1007/s13233-012-0090-6

The purpose of this study was to evaluate the effects of a GENESIS-BCPTM scaffold composed of hydroxyapatite (HAp) and β-tricalcium phosphate (β-TCP) on bone formation. The rela tive ratio of components forming GENESIS-BCPTM was investigated by confirming the molar ratio of Ca/P through energy dispersive spectrometer (EDS) analysis. The results being that the scaffold is comprised of 60% HAp and 40% β-TCP. Moreover,scanning electron microscopy (SEM) images showed a unique surface morphology similar to a soccer ball. X-ray diffraction (XRD) analysis showed that the porosity, crystallinity, and Ca/P ratio were 65.5%, 84.9%, and 1.61%,respectively. In vitro tests including cytotoxicity and cell proliferation showed a good biocompatibility of GENESIS-BCPTM. In vivo tests, including mouse skull test, and hematoxylin and eosin stains of GENESIS-BCPTM implanted in rabbit and human subjects showed that the bone graft is effective to accelerate new bone formation. It was concluded that GENESIS-BCPTM can be used as an effective alloplast bone graft. KCI Citation Count: 6