Low-dose Radiation Attenuates Chemical Mutagenesis In Vivo# -Cross Adaptation

The biological effects of low-dose radiation are not only of social concern but also of scientific interest. The radioadaptive response, which is defined as an increased radioresistance by prior exposure to low-dose radiation, has been extensively studied both in vitro and in vivo. Here we briefly r...

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Published inJOURNAL OF RADIATION RESEARCH Vol. 50; no. 5; pp. 401 - 405
Main Authors Kakinuma, Shizuko, Yamauchi, Kazumi, Amasaki, Yoshiko, Nishimura, Mayumi, Shimada, Yoshiya
Format Journal Article
LanguageEnglish
Published THE JAPAN RADIATION RESEARCH SOCIETY 01.09.2009
Subjects
Adaptations
Alkylating agents
Carcinogenesis
Cell survival
Ethyl nitrosourea
Mutagenesis
Mutation
Radiation
Radioresistance
Reviews
Thymus
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Summary:The biological effects of low-dose radiation are not only of social concern but also of scientific interest. The radioadaptive response, which is defined as an increased radioresistance by prior exposure to low-dose radiation, has been extensively studied both in vitro and in vivo. Here we briefly review the radioadaptive response with respect to mutagenesis, survival rate, and carcinogenesis in vivo, and introduce our recent findings of cross adaptation in mouse thymic cells, that is, the suppressive effect of repeated low-dose radiation on mutation induction by the alkylating agent N-ethyl-N-nitrosourea.
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ISSN:0449-3060
1349-9157
DOI:10.1269/jrr.09051