A Large Language Model-Based Generative Natural Language Processing Framework Finetuned on Clinical Notes Accurately Extracts Headache Frequency from Electronic Health Records

• Published in: medRxiv : the preprint server for health sciences
• Main Authors: Chiang, Chia-Chun, Luo, Man, Dumkrieger, Gina, Trivedi, Shubham, Chen, Yi-Chieh, Chao, Chieh-Ju, Schwedt, Todd J, Sarker, Abeed, Banerjee, Imon
• Format: Journal Article
• Language: English
• Published: United States 03.10.2023
• Subjects: migraine; headache frequency; natural language processing; large language model; artificial intelligence
• DOI: 10.1101/2023.10.02.23296403

Headache frequency, defined as the number of days with any headache in a month (or four weeks), remains a key parameter in the evaluation of treatment response to migraine preventive medications. However, due to the variations and inconsistencies in documentation by clinicians, significant challenges exist to accurately extract headache frequency from the electronic health record (EHR) by traditional natural language processing (NLP) algorithms. This was a retrospective cross-sectional study with human subjects identified from three tertiary headache referral centers- Mayo Clinic Arizona, Florida, and Rochester. All neurology consultation notes written by more than 10 headache specialists between 2012 to 2022 were extracted and 1915 notes were used for model fine-tuning (90%) and testing (10%). We employed four different NLP frameworks: (1) (2) Generative Pre-Trained Transformer-2 ( fine-tuned on Mayo Clinic notes; and fine-tuned on Mayo Clinic notes to generate the answer by considering the context of included text. The GPT-2 generative model was the best-performing model with an accuracy of 0.92[0.91 - 0.93] and R score of 0.89[0.87, 0.9], and all GPT2-based models outperformed the ClinicalBERT model in terms of the exact matching accuracy. Although the ClinicalBERT regression model had the lowest accuracy 0.27[0.26 - 0.28], it demonstrated a high R score 0.88[0.85, 0.89], suggesting the ClinicalBERT model can reasonably predict the headache frequency within a range of ≤ ± 3 days, and the R score was higher than the GPT-2 QA zero-shot model or GPT-2 QA model few-shot training fine-tuned model. We developed a robust model based on a state-of-the-art large language model (LLM)- a GPT-2 generative model that can extract headache frequency from EHR free-text clinical notes with high accuracy and R score. It overcame several challenges related to different ways clinicians document headache frequency that were not easily achieved by traditional NLP models. We also showed that GPT2-based frameworks outperformed ClinicalBERT in terms of accuracy in extracting headache frequency from clinical notes. To facilitate research in the field, we released the GPT-2 generative model and inference code with open-source license of community use in GitHub.