Effect of cisapride on gastric emptying in diabetic patients without gastrointestinal symptoms

The long-team effects of cisapride on gastric emptying and hormonal interaction in diabetic patients without gastrointestinal symptoms was evaluated. Gastric emptying was determined by the N-acetyl-p-amino-phenol (APAP) method before and after cisapride treatment. Gastric emptying improved significa...

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Bibliographic Details
Published inTokai journal of experimental and clinical medicine Vol. 16; no. 2; p. 97
Main Authors Kasai, S, Tanaka, K, Machimura, H, Takeda, H, Kaneshige, H, Sakai, H, Harasawa, S
Format Journal Article
LanguageEnglish
Published Japan 01.07.1991
Subjects
Acetaminophen - administration & dosage
Acetaminophen - blood
Blood Glucose - metabolism
Cisapride
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - physiopathology
Female
Gastric Emptying - drug effects
Glucose Tolerance Test
Humans
Insulin - blood
Insulin - metabolism
Insulin Secretion
Male
Middle Aged
Piperidines - therapeutic use
Serotonin Antagonists - therapeutic use
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Summary:The long-team effects of cisapride on gastric emptying and hormonal interaction in diabetic patients without gastrointestinal symptoms was evaluated. Gastric emptying was determined by the N-acetyl-p-amino-phenol (APAP) method before and after cisapride treatment. Gastric emptying improved significantly, from 5.95 to 8.04 micrograms/ml, after 6 weeks of treatment. Plasma concentrations of immunoreactive insulin (IRI), after 30 and 45 minutes in the gastric emptying test, increased significantly after treatment. It appeared that improvement of gastric emptying after loading with cisapride might be related to improved insulin secretion in diabetic patients without subjective symptoms of gastroparesis.
ISSN:0385-0005