Improvement of measurement method for hydroxylated polychlorinated biphenyls (OH-PCBs) in blood samples using LC/MS/MS

Hydroxylated polychlorinated biphenyls (OH-PCBs) are well known as metabolites of PCBs in the human body. We improved a measurement method for OH-PCBs in blood samples using LC/MS/MS. A new 2 microm particle column was used, and the analytical conditions for the LC/MS/MS measurements were optimized....

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Published inFukuoka igaku zasshi = Hukuoka acta medica Vol. 104; no. 4; p. 128
Main Authors Tobiishi, Kazuhiro, Suzuki, Shigeru, Todaka, Takashi, Hirakawa, Hironori, Hori, Tsuguhide, Kajiwara, Jumboku, Hirata, Teruaki, Iida, Takao, Uchi, Hiroshi, Furue, Masutaka
Format Journal Article
LanguageEnglish
Published Japan 25.04.2013
Subjects
Chemistry Techniques, Analytical - methods
Chromatography, Liquid
Humans
Hydroxylation
Polychlorinated Biphenyls - blood
Tandem Mass Spectrometry
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Abstract Hydroxylated polychlorinated biphenyls (OH-PCBs) are well known as metabolites of PCBs in the human body. We improved a measurement method for OH-PCBs in blood samples using LC/MS/MS. A new 2 microm particle column was used, and the analytical conditions for the LC/MS/MS measurements were optimized. The improved method is more sensitive than the conventional method for 5g blood samples. And, this method is effective at determining the concentrations of OH-PCBs, PCBs and dioxins from the same sample without special treatment of the sample such as derivatization.
AbstractList Hydroxylated polychlorinated biphenyls (OH-PCBs) are well known as metabolites of PCBs in the human body. We improved a measurement method for OH-PCBs in blood samples using LC/MS/MS. A new 2 microm particle column was used, and the analytical conditions for the LC/MS/MS measurements were optimized. The improved method is more sensitive than the conventional method for 5g blood samples. And, this method is effective at determining the concentrations of OH-PCBs, PCBs and dioxins from the same sample without special treatment of the sample such as derivatization.
Author Suzuki, Shigeru
Todaka, Takashi
Hirakawa, Hironori
Iida, Takao
Hori, Tsuguhide
Furue, Masutaka
Tobiishi, Kazuhiro
Kajiwara, Jumboku
Hirata, Teruaki
Uchi, Hiroshi
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  organization: Fukuoka Institute of Health and Environmental Sciences, 39 Mukaizano, Dazaifu, Fukuoka, Japan. tobiishi@fihes.pref.fukuoka.jp
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/23858791$$D View this record in MEDLINE/PubMed
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Snippet Hydroxylated polychlorinated biphenyls (OH-PCBs) are well known as metabolites of PCBs in the human body. We improved a measurement method for OH-PCBs in blood...
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StartPage 128
SubjectTerms Chemistry Techniques, Analytical - methods
Chromatography, Liquid
Humans
Hydroxylation
Polychlorinated Biphenyls - blood
Tandem Mass Spectrometry
Title Improvement of measurement method for hydroxylated polychlorinated biphenyls (OH-PCBs) in blood samples using LC/MS/MS
URI https://www.ncbi.nlm.nih.gov/pubmed/23858791
Volume 104
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