Improvement of measurement method for hydroxylated polychlorinated biphenyls (OH-PCBs) in blood samples using LC/MS/MS

Hydroxylated polychlorinated biphenyls (OH-PCBs) are well known as metabolites of PCBs in the human body. We improved a measurement method for OH-PCBs in blood samples using LC/MS/MS. A new 2 microm particle column was used, and the analytical conditions for the LC/MS/MS measurements were optimized....

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Bibliographic Details
Published inFukuoka igaku zasshi = Hukuoka acta medica Vol. 104; no. 4; p. 128
Main Authors Tobiishi, Kazuhiro, Suzuki, Shigeru, Todaka, Takashi, Hirakawa, Hironori, Hori, Tsuguhide, Kajiwara, Jumboku, Hirata, Teruaki, Iida, Takao, Uchi, Hiroshi, Furue, Masutaka
Format Journal Article
LanguageEnglish
Published Japan 25.04.2013
Subjects
Chemistry Techniques, Analytical - methods
Chromatography, Liquid
Humans
Hydroxylation
Polychlorinated Biphenyls - blood
Tandem Mass Spectrometry
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Summary:Hydroxylated polychlorinated biphenyls (OH-PCBs) are well known as metabolites of PCBs in the human body. We improved a measurement method for OH-PCBs in blood samples using LC/MS/MS. A new 2 microm particle column was used, and the analytical conditions for the LC/MS/MS measurements were optimized. The improved method is more sensitive than the conventional method for 5g blood samples. And, this method is effective at determining the concentrations of OH-PCBs, PCBs and dioxins from the same sample without special treatment of the sample such as derivatization.
ISSN:0016-254X