Antibody Responses in Seropositive Persons after a Single Dose of SARS-CoV-2 mRNA Vaccine

Some persons who have recovered from Covid-19 have antibodies to the spike protein of SARS-CoV-2. In 43 such persons who had received a first mRNA vaccine dose, high levels of neutralizing antispike antibodies were produced — in many cases even higher than after a second dose in 67 persons without b...

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Published inThe New England journal of medicine Vol. 384; no. 14; pp. 1372 - 1374
Main Authors Krammer, Florian, Srivastava, Komal, Alshammary, Hala, Amoako, Angela A, Awawda, Mahmoud H, Beach, Katherine F, Bermúdez-González, Maria C, Bielak, Dominika A, Carreño, Juan M, Chernet, Rachel L, Eaker, Lily Q, Ferreri, Emily D, Floda, Daniel L, Gleason, Charles R, Hamburger, Joshua Z, Jiang, Kaijun, Kleiner, Giulio, Jurczyszak, Denise, Matthews, Julia C, Mendez, Wanni A, Nabeel, Ismail, Mulder, Lubbertus C.F, Raskin, Ariel J, Russo, Kayla T, Salimbangon, Ashley-Beathrese T, Saksena, Miti, Shin, Amber S, Singh, Gagandeep, Sominsky, Levy A, Stadlbauer, Daniel, Wajnberg, Ania, Simon, Viviana
Format Journal Article
LanguageEnglish
Published Boston Massachusetts Medical Society 08.04.2021
Subjects
Age
Antibodies
Coronaviruses
COVID-19
Influenza
mRNA
mRNA vaccines
Pain
Polls & surveys
Severe acute respiratory syndrome coronavirus 2
Spike protein
Vaccination
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Summary:Some persons who have recovered from Covid-19 have antibodies to the spike protein of SARS-CoV-2. In 43 such persons who had received a first mRNA vaccine dose, high levels of neutralizing antispike antibodies were produced — in many cases even higher than after a second dose in 67 persons without baseline antibodies to the virus. Systemic reactions were more common in those seropositive before vaccination.
Bibliography:SourceType-Scholarly Journals-1
ObjectType-Correspondence-1
content type line 14
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMc2101667