Reframing Immune-Mediated Inflammatory Diseases through Signature Cytokine Hubs
The ability to block specific cytokine pathways has revealed pathophysiological differences among autoimmune diseases (e.g., the efficacy of TNF inhibitors in arthritides and inflammatory bowel disorders and their inefficacy in giant-cell arteritis and multiple sclerosis), providing a framework for...
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Published in | The New England journal of medicine Vol. 385; no. 7; pp. 628 - 639 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Boston
Massachusetts Medical Society
12.08.2021
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Subjects | |
Online Access | Get full text |
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Summary: | The ability to block specific cytokine pathways has revealed pathophysiological differences among autoimmune diseases (e.g., the efficacy of TNF inhibitors in arthritides and inflammatory bowel disorders and their inefficacy in giant-cell arteritis and multiple sclerosis), providing a framework for reclassification. |
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ISSN: | 0028-4793 1533-4406 |
DOI: | 10.1056/NEJMra1909094 |