Synthesis of Selenium-Containing Polyphenolic Acid Esters and Evaluation of Their Effects on Antioxidation and 5-Lipoxygenase Inhibition

Six novel selenium-containing polyphenolic acid esters were synthesized and evaluated as antioxidants and 5-lipoxygenase inhibitors. Synthesis of the title compounds involved the Mitsunobu reaction of polyphenolic acids (4-8, 14) with 2-phenylselenoethanol (3). Compounds 22, 23, and 25 were found to...

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Published inChemical & Pharmaceutical Bulletin Vol. 53; no. 11; pp. 1402 - 1407
Main Authors Chi-Fu LINa, Tsu-Chung CHANGb, Chih-Chia CHIANGc, Hou-Jen TSAIc, Ling-Yih HSUa
Format Journal Article
LanguageJapanese
Published Pharmaceutical Society of Japan 2005
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Summary:Six novel selenium-containing polyphenolic acid esters were synthesized and evaluated as antioxidants and 5-lipoxygenase inhibitors. Synthesis of the title compounds involved the Mitsunobu reaction of polyphenolic acids (4-8, 14) with 2-phenylselenoethanol (3). Compounds 22, 23, and 25 were found to be very effective antioxidants and 5-lipoxygenase inhibitors with activity comparable to or better than caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE).
ISSN:0009-2363